Publications:
Tegowski M, Prater AK, Holley CL, Meyer KD. Single-cell m6A profiling in the mouse brain uncovers cell type-specific RNA methylomes and age-dependent differential methylation. Nature Neuroscience. 2024 Sep 24. Read it here. Read press/other articles highlighting this work here.
Marayati BF, Thompson MG, Holley CL, Horner SM, Meyer KD. Programmable protein expression using a genetically encoded m6A sensor. Nature Biotechnology. 2024 Jan 2. Read it here. Read press/other articles highlighting this work here and here.
Sheehan CJ, Marayati BF, Bhatia J, and Meyer KD. In situ visualization of m6A sites in cellular mRNAs. Nucleic Acids Research. 2023. Read it here.
Flamand MN, Tegowski M, Meyer KD. The Proteins of mRNA Modification: Writers, Readers, and Erasers. Annu Rev Biochem. 2023. Epub 20230417. Read it here.
Flamand, M.N., Ke, K., Tamming, R., and Meyer, K.D. Single-molecule identification of the target RNAs of different RNA binding proteins simultaneously in cells. Genes and Development 2022. Read it here.
Tegowski, M., Meyer, K.D. Detection of m6A in single cultured cells using scDART-seq. STAR Protocols. 3 (3) 16 Sep 2022.
Flamand, M.N. and Meyer, K.D. m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs. Nucleic Acids Research. 2022. Read it here.
Choi S.H., Flamand M.N., Liu B., Zhu H., Hu M., Wang M., Sewell J., Holley C.L.., Al-Hashimi H.M., Meyer K.D. RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs. Cell Reports. 40 (9):111293. 2022. Read it here.
Zhu, H., Yin, X., Holley, C.L., and Meyer, K.D. Improved methods for deamination-based m6A detection. Frontiers in Cell and Developmental Biology. 28 Mar 2022. doi: 10.3389/fcell.2022.888279.
Tegowski, M., Flamand, M.N., Meyer, K.D. scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells. Molecular Cell. 82 (4): 868-878, 2022. Read it here
Sachithrani, U.M., Meyer, K.D., Wang, D.O., Bredy, T.W. RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain. Trends in Neurosciences. 43 (12): 1011-1023, 2020.
Meyer, K.D. DART-seq: an antibody-free method for global m6A detection. Nature Methods. 16: 1275–1280, 2019. Read it here
Flamand, MN, Meyer KD. The epitranscriptome and synaptic plasticity. Current Opinion in Neurobiology 59: 41-48, 2019. Read it here
Meyer, K.D. m6A-mediated translation regulation. Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms. 1862 (3):301-309. 2018.
Liu B., Merriman D.K., Choi S.H., Schumacher M.A., Plangger R., Kreutz C,. Horner S.M., Meyer K.D., Al-Hashimi H.M. A potentially abundant junctional motif stabilized by m6A and Mg2. Nature Communications 9 (1): 2761, 2018.
Previous Publications
Meyer, K.D. and Jaffrey, S.R. Rethinking m6A Readers, Writers, and Erasers. Annual Review of Cell and Developmental Biology 33 (1): 319-342, 2017.
Meyer, K.D., Patil, D.P., Zhou, J., Zinoviev, A., Skabkin, M.A., Elemento, O., Pestova, T.V., Qian, S., Jaffrey, S.R. 5'UTR m6A promotes cap-independent translation. Cell 163 (4): 999-1010, 2015. (Previewed by Sarah Mitchell and Roy Parker: Cell).
Satterlee, J.S., Basanta-Sanchez, M., Blanco, S., Li, J.B., Meyer, K.D., Pollock, J., Sadri-Vakili, G., Rybak-Wolf, A. Novel RNA modifications in the nervous system: form and function. J Neurosci 34 (46): 15170-15177, 2014.
Meyer, K.D. and Jaffrey, S.R. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nature Reviews Molecular Cell Biology 15 (5): 313-326, 2014.
Hess, M.E., Hess, S., Meyer, K.D., Verhagen, L.A., Koch, L., Brönneke, H.S., Dietrich, M.O., Jordan, S.D., Saletore, Y., Elemento, O., Belgardt, B.F., Franz, T., Horvath, T.L., Rüther U., Jaffrey, S.R., Kloppenburg, P., Brüning, J.C. The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nature Neuroscience 16 (8): 1042-1048, 2013.
Saletore, Y., Meyer, K.D., Korlach, J., Vilfan, I.D., Jaffrey, S.R., Mason, C.E. The birth of the epitranscriptome: deciphering the function of RNA modifications. Genome Biology 13 (10): 175, 2012.
Meyer, K.D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C.E., Jaffrey, S.R. Comprehensive analysis of mRNA methylation reveals pervasive adenosine methylation in 3’ UTRs. Cell 149 (7): 1635-1646, 2012.